Complement Fixation in the Diagnosis of Gonococcal Infections

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Evaluation of the gonococcal complement-fixation test.

The gonococcal complement-fixation test (GCFT), based on the same principle as the Wassermann reaction (WR), has been in use for over 60 years. The test was applied for the first time, using a culture of the gonococcus as antigen, by Muller and Oppenheim (1906) to establish the diagnosis in a case of arthritis. Teague and Torrey (1907) suggested that negative results in the GCFT were due to dif...

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Gonococcal Complement-fixation Test in Complicated and Uncomplicated Gonorrhoea.

The complement-fixation reaction with gonococcal antigen (gonococcal complement-fixation test: GCFI) is based on the same serological principle, and has been known for about as long, as the Wassermann reaction. Up to the 1940's the GCFT was widely employed, but as improvements in cultivation techniques for gonococci were developed, interest in the complement-fixation reaction diminished. At pre...

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The Complement Fixation Test in the Diagnosis of Virus Infections of the Central Nervous System

A specific complement fixation test can be obtained in various central nervous system virus infections by using as antigens emulsions of infected brain tissue, freezing and thawing the brain emulsion, and then centrifuging it in an angle head centrifuge at 3500 R.P.M. for 1 hour. The method has proved reliable in the case of rabies, St. Louis encephalitis, Japanese B encephalitis, lymphocytic c...

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ژورنال

عنوان ژورنال: Journal of Infectious Diseases

سال: 1915

ISSN: 0022-1899,1537-6613

DOI: 10.1093/infdis/16.2.303